Introduction of Hereditary Disease-Associated Mutations into the β-Amyloid Precursor Protein Gene of Mouse Embryonic Stem Cells: a Comparison of Homologous Recombination Methods

Two different approaches for introducing pathogenic mutations into the β-amyloid precursor protein gene in mouse embryonic stem cells were compared. Both approaches require two sequential modifications of the targeting locus by homologous recombinations. One approach was a “targeting-in-out” procedu...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Gschwind, Martin, Huber, Gerda
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1998
Fag:	Cell Growth and Development
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109051/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671475/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.8.4651
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