Introduction of Hereditary Disease-Associated Mutations into the β-Amyloid Precursor Protein Gene of Mouse Embryonic Stem Cells: a Comparison of Homologous Recombination Methods
Two different approaches for introducing pathogenic mutations into the β-amyloid precursor protein gene in mouse embryonic stem cells were compared. Both approaches require two sequential modifications of the targeting locus by homologous recombinations. One approach was a “targeting-in-out” procedu...
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| Publicat a: | Mol Cell Biol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
1998
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109051/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671475/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.8.4651 |
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