Introduction of Hereditary Disease-Associated Mutations into the β-Amyloid Precursor Protein Gene of Mouse Embryonic Stem Cells: a Comparison of Homologous Recombination Methods

Two different approaches for introducing pathogenic mutations into the β-amyloid precursor protein gene in mouse embryonic stem cells were compared. Both approaches require two sequential modifications of the targeting locus by homologous recombinations. One approach was a “targeting-in-out” procedu...

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Опубліковано в::	Mol Cell Biol
Автори:	Gschwind, Martin, Huber, Gerda
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Taylor & Francis 1998
Предмети:	Cell Growth and Development
Онлайн доступ:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109051/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671475/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.8.4651
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