Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

We have examined the effects of core histone acetylation on the transcriptional activity and higher-order folding of defined 12-mer nucleosomal arrays. Purified HeLa core histone octamers containing an average of 2, 6, or 12 acetates per octamer (8, 23, or 46% maximal site occupancy, respectively) w...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Tse, Christin, Sera, Takashi, Wolffe, Alan P., Hansen, Jeffrey C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1998
Assuntos:	Transcriptional Regulation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109049/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671473/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.8.4629
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