Involvement of p53 and p21 in Cellular Defects and Tumorigenesis in Atm(−/−) Mice

Disruption of the mouse Atm gene, whose human counterpart is consistently mutated in ataxia-telangiectasia (A-T) patients, creates an A-T mouse model exhibiting most of the A-T-related systematic and cellular defects. While ATM plays a major role in signaling the p53 response to DNA strand break dam...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Xu, Yang, Yang, Eva Marie, Brugarolas, James, Jacks, Tyler, Baltimore, David
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1998
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109022/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9632822/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.7.4385
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!