p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin.

Consistent with the excellent clinical results in testicular germ cell tumors (TGCT), most cell lines derived from this cancer show an exquisite sensitivity to Cisplatin. It is well accepted that the high susceptibility of TGCT cells to apoptosis plays a central role in this hypersensitive phenotype...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Matthias Gutekunst, Moshe Oren, Andrea Weilbacher, Michael A Dengler, Christiane Markwardt, Jürgen Thomale, Walter E Aulitzky, Heiko van der Kuip
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2011-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	http://europepmc.org/articles/PMC3080918?pdf=render
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