Involvement of p53 and p21 in Cellular Defects and Tumorigenesis in Atm(−/−) Mice
Disruption of the mouse Atm gene, whose human counterpart is consistently mutated in ataxia-telangiectasia (A-T) patients, creates an A-T mouse model exhibiting most of the A-T-related systematic and cellular defects. While ATM plays a major role in signaling the p53 response to DNA strand break dam...
Guardat en:
| Publicat a: | Mol Cell Biol |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
1998
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109022/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9632822/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.7.4385 |
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