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14-3-3 Facilitates Ras-Dependent Raf-1 Activation In Vitro and In Vivo

14-3-3 proteins complex with many signaling molecules, including the Raf-1 kinase. However, the role of 14-3-3 in regulating Raf-1 activity is unclear. We show here that 14-3-3 is bound to Raf-1 in the cytosol but is totally displaced when Raf-1 is recruited to the plasma membrane by oncogenic mutan...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Roy, Sandrine, McPherson, Robert A., Apolloni, Ann, Yan, Jun, Lane, Annette, Clyde-Smith, Jodi, Hancock, John F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 1998
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC108979/
https://ncbi.nlm.nih.gov/pubmed/9632779
Tagiau: Ychwanegu Tag
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