14-3-3 Facilitates Ras-Dependent Raf-1 Activation In Vitro and In Vivo

14-3-3 proteins complex with many signaling molecules, including the Raf-1 kinase. However, the role of 14-3-3 in regulating Raf-1 activity is unclear. We show here that 14-3-3 is bound to Raf-1 in the cytosol but is totally displaced when Raf-1 is recruited to the plasma membrane by oncogenic mutan...

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Εκδόθηκε σε:	Mol Cell Biol
Κύριοι συγγραφείς:	Roy, Sandrine, McPherson, Robert A., Apolloni, Ann, Yan, Jun, Lane, Annette, Clyde-Smith, Jodi, Hancock, John F.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Taylor & Francis 1998
Θέματα:	Cell Growth and Development
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108979/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9632779/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.7.3947
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