Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

Interactions between B and T cells are essential for most antibody responses, but the dynamics of these interactions are poorly understood. By two-photon microscopy of intact lymph nodes, we show that upon exposure to antigen, B cells migrate with directional preference toward the B-zone–T-zone boun...

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Main Authors: Okada, Takaharu, Miller, Mark J, Parker, Ian, Krummel, Matthew F, Neighbors, Margaret, Hartley, Suzanne B, O'Garra, Anne, Cahalan, Michael D, Cyster, Jason G
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2005
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1088276/
https://ncbi.nlm.nih.gov/pubmed/15857154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0030150
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