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Activation of Protein Kinase C Triggers Its Ubiquitination and Degradation

Treatment of cells with tumor-promoting phorbol esters results in the activation but then depletion of phorbol ester-responsive protein kinase C (PKC) isoforms. The ubiquitin-proteasome pathway has been implicated in regulating the levels of many cellular proteins, including those involved in cell c...

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Autors principals: Lu, Zhimin, Liu, David, Hornia, Armand, Devonish, Wayne, Pagano, Michele, Foster, David A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC108795/
https://ncbi.nlm.nih.gov/pubmed/9447980
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