Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts

3Y1 rat fibroblasts overexpressing the epidermal growth factor (EGF) receptor (EGFR cells) become transformed when treated with EGF. A common response to oncogenic and mitogenic stimuli is elevated phospholipase D (PLD) activity. RalA, a small GTPase that functions as a downstream effector molecule...

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Main Authors: Lu, Zhimin, Hornia, Armand, Joseph, Troy, Sukezane, Taiko, Frankel, Paul, Zhong, Minghao, Bychenok, Sergei, Xu, Lizhong, Feig, Larry A., Foster, David A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC85102/
https://ncbi.nlm.nih.gov/pubmed/10611224
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