Should We Use N-Acetyltransferase Type 2 Genotyping To Personalize Isoniazid Doses?

Isoniazid is metabolized by the genetically polymorphic arylamine N-acetyltransferase type 2 (NAT2). A greater number of high-activity alleles are related to increased acetylation capacity and in some reports to low efficacy and toxicity of isoniazid. The objective of this study was to assess indivi...

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Detalhes bibliográficos
Main Authors: Kinzig-Schippers, Martina, Tomalik-Scharte, Dorota, Jetter, Alexander, Scheidel, Bernhard, Jakob, Verena, Rodamer, Michael, Cascorbi, Ingolf, Doroshyenko, Oxana, Sörgel, Fritz, Fuhr, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087660/
https://ncbi.nlm.nih.gov/pubmed/15855489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1733-1738.2005
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