Intracellular Substrates for the Primer-Unblocking Reaction by Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Detection and Quantitation in Extracts from Quiescent- and Activated-Lymphocyte Subpopulations

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected patients with 3′-azido-3′-deoxythymidine (AZT) selects for mutant forms of viral reverse transcriptase (RT) with increased ability to remove chain-terminating nucleotides from blocked DNA chains. We tested various cell extracts for th...

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Detalhes bibliográficos
Main Authors: Smith, Anthony J., Meyer, Peter R., Asthana, Deshratn, Ashman, Margarita R., Scott, Walter A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087649/
https://ncbi.nlm.nih.gov/pubmed/15855493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1761-1769.2005
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