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Dual Targeting of Topoisomerase IV and Gyrase To Reduce Mutant Selection: Direct Testing of the Paradigm by Using WCK-1734, a New Fluoroquinolone, and Ciprofloxacin

Quinolones that act equally against DNA gyrase and topoisomerase IV are a desirable modality to decrease the selection of resistant strains. We first determined by genetic and biochemical studies in Staphylococcus aureus that the primary target enzyme of WCK-1734, a new quinolone, was DNA gyrase. A...

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Detaylı Bibliyografya
Asıl Yazarlar: Strahilevitz, Jacob, Hooper, David C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2005
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087631/
https://ncbi.nlm.nih.gov/pubmed/15855518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1949-1956.2005
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