Generation of Attenuated Mycobacterium bovis Strains by Signature-Tagged Mutagenesis for Discovery of Novel Vaccine Candidates

Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex, has a particularly wide host range and causes tuberculosis in most mammals, including humans. A signature tag mutagenesis approach, which employed illegitimate recombination and infection of guinea pigs, was applied to M. bovis...

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Detalhes bibliográficos
Main Authors: Collins, Desmond M., Skou, Bronwyn, White, Stefan, Bassett, Shalome, Collins, Lauren, For, Raewyn, Hurr, Kathryn, Hotter, Grant, de Lisle, Geoffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087418/
https://ncbi.nlm.nih.gov/pubmed/15784584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.4.2379-2386.2005
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