Transposon Mutagenesis of Mb0100 at the ppe1-nrp Locus in Mycobacterium bovis Disrupts Phthiocerol Dimycocerosate (PDIM) and Glycosylphenol-PDIM Biosynthesis, Producing an Avirulent Strain with Vaccine Properties At Least Equal to Those of M. bovis BCG

The unusual and complex cell wall of pathogenic mycobacteria plays a major role in pathogenesis, with specific complex lipids acting as defensive, offensive, or adaptive effectors of virulence. The phthiocerol and phthiodiolone dimycocerosate esters (PDIMs) comprise one such category of virulence-en...

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Detalhes bibliográficos
Main Authors: Hotter, Grant S., Wards, Barry J., Mouat, Pania, Besra, Gurdyal S., Gomes, Jessica, Singh, Monica, Bassett, Shalome, Kawakami, Pamela, Wheeler, Paul R., de Lisle, Geoffrey W., Collins, Desmond M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Molecular Biology of Pathogens
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1065232/
https://ncbi.nlm.nih.gov/pubmed/15774869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.7.2267-2277.2005
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