Modulation of Enzymatic Activity and Biological Function of Listeria monocytogenes Broad-Range Phospholipase C by Amino Acid Substitutions and by Replacement with the Bacillus cereus Ortholog

The secreted broad-range phosphatidylcholine (PC)-preferring phospholipase C (PC-PLC) of Listeria monocytogenes plays a role in the bacterium’s ability to escape from phagosomes and spread from cell to cell. Based on comparisons with two orthologs, Clostridium perfringens α-toxin and Bacillus cereus...

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Bibliographic Details
Main Authors: Zückert, Wolfram R., Marquis, Hélène, Goldfine, Howard
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Molecular and Cellular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC108596/
https://ncbi.nlm.nih.gov/pubmed/9746585
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