Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G(2)/M Promoters

In response to DNA damage, p53 activates G(1)/S blocking and apoptotic genes through sequence-specific binding. p53 also represses genes with no target site, such as those for Cdc2 and cyclin B, key regulators of the G(2)/M transition. Like most G(2)/M promoters, they rely on multiple CCAAT boxes ac...

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Detalhes bibliográficos
Main Authors: Imbriano, Carol, Gurtner, Aymone, Cocchiarella, Fabienne, Di Agostino, Silvia, Basile, Valentina, Gostissa, Monica, Dobbelstein, Matthias, Del Sal, Giannino, Piaggio, Giulia, Mantovani, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084283/
https://ncbi.nlm.nih.gov/pubmed/15831478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3737-3751.2005
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