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Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse
Transgenic mice have been used to explore the role of chromosomal translocations in the genesis of tumors. But none of these efforts has actually involved induction of a translocation in vivo. Here we report the use of Cre recombinase to replicate in vivo the t(8;21) translocation found in human acu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1084259/ https://ncbi.nlm.nih.gov/pubmed/11265752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd027 |
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