Initial activation of cyclin-B1–cdc2 kinase requires phosphorylation of cyclin B1

At the G(2)/M transition of the cell cycle, the cdc25c phosphatase dephosphorylates inhibitory residues of cdc2, and cyclin-B–cdc2 kinase (MPF) is activated. Phosphorylation of cyclin B1 induces its nuclear accumulation, and, since cdc25c is also believed to accumulate and activate shortly before G(...

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Main Authors: Peter, Marion, Le Peuch, Christian, Labbé, Jean-Claude, Meyer, April N., Donoghue, Daniel J., Dorée, Marcel
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2002
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084145/
https://ncbi.nlm.nih.gov/pubmed/12034754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf111
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