Rectal and Intranasal Immunizations with Recombinant Urease Induce Distinct Local and Serum Immune Responses in Mice and Protect against Helicobacter pylori Infection

To determine the optimal inductive sites for immunization against Helicobacter pylori infection, the protective efficacy of recombinant urease (rUre) was assessed for mice given the vaccine by either the oral (p.o.), intranasal (i.n.), or rectal route. When mice were immunized with rUre (25 μg p.o....

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Main Authors: Kleanthous, Harry, Myers, Gwendolyn A., Georgakopoulos, Kathleen M., Tibbitts, Timothy J., Ingrassia, Jennifer W., Gray, Heather L., Ding, Ru, Zhang, Zhen-Zi, Lei, Wende, Nichols, Richard, Lee, Cynthia K., Ermak, Thomas H., Monath, Thomas P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1998
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC108285/
https://ncbi.nlm.nih.gov/pubmed/9596763
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