Rectal and Intranasal Immunizations with Recombinant Urease Induce Distinct Local and Serum Immune Responses in Mice and Protect against Helicobacter pylori Infection

To determine the optimal inductive sites for immunization against Helicobacter pylori infection, the protective efficacy of recombinant urease (rUre) was assessed for mice given the vaccine by either the oral (p.o.), intranasal (i.n.), or rectal route. When mice were immunized with rUre (25 μg p.o....

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Detalhes bibliográficos
Main Authors: Kleanthous, Harry, Myers, Gwendolyn A., Georgakopoulos, Kathleen M., Tibbitts, Timothy J., Ingrassia, Jennifer W., Gray, Heather L., Ding, Ru, Zhang, Zhen-Zi, Lei, Wende, Nichols, Richard, Lee, Cynthia K., Ermak, Thomas H., Monath, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC108285/
https://ncbi.nlm.nih.gov/pubmed/9596763
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