Linked Tumor-Selective Virus Replication and Transgene Expression from E3-Containing Oncolytic Adenoviruses

Historically, the adenoviral E3 region was found to be nonessential for viral replication in vitro. In addition, adenoviruses whose genome was more than approximately 105% the size of the native genome were inefficiently packaged. These profound observations were used experimentally to insert transg...

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Opis bibliograficzny
Główni autorzy: Zhu, Mingzhu, Bristol, J. Andrew, Xie, Yuefeng, Mina, Mervat, Ji, Hong, Forry-Schaudies, Suzanne, Ennist, David L.
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology 2005
Hasła przedmiotowe:
Gene Delivery
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1082742/
https://ncbi.nlm.nih.gov/pubmed/15827160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.9.5455-5465.2005
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