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Bivalency Is Required for Anticapsular Monoclonal Antibodies To Optimally Suppress Activation of the Alternative Complement Pathway by the Cryptococcus neoformans Capsule

Encapsulated cells of Cryptococcus neoformans are potent activators of the alternative complement pathway. Previous studies found that monoclonal antibodies (MAbs) specific for the major capsular polysaccharide, termed glucuronoxylomannan (GXM), can markedly suppress the ability of the capsule to ac...

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Udgivet i:Infect Immun
Principais autores: Kozel, Thomas R., MacGill, Randall S., Wall, Kevin K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Fungal and Parasitic Infections
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108087/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9529080/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.4.1547-1553.1998
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