Enhanced Protective Antibody Responses to PspA after Intranasal or Subcutaneous Injections of PspA Genetically Fused to Granulocyte-Macrophage Colony-Stimulating Factor or Interleukin-2

Antibody to pneumococcal surface protein A (PspA) has been shown to be protective for Streptococcus pneumoniae infections in mice. In an attempt to define a model for inducing protective antibody to PspA in the absence of adjuvant, we designed two genetic fusions, PspA–interleukin-2 [IL-2]) and PspA...

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Pubblicato in:	Infect Immun
Autori principali:	Wortham, Charles, Grinberg, Luba, Kaslow, David C., Briles, David E., McDaniel, Larry S., Lees, Andrew, Flora, Michael, Snapper, Clifford M., Mond, James J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Microbial Immunity and Vaccines
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108082/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9529075/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.4.1513-1520.1998
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