Intranasal Administration of a Meningococcal Outer Membrane Vesicle Vaccine Induces Persistent Local Mucosal Antibodies and Serum Antibodies with Strong Bactericidal Activity in Humans

A nasal vaccine, consisting of outer membrane vesicles (OMVs) from group B Neisseria meningitidis, was given to 12 volunteers in the form of nose drops or nasal spray four times at weekly intervals, with a fifth dose 5 months later. Each nasal dose consisted of 250 μg of protein, equivalent to 10 ti...

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Bibliografische Detailangaben

Veröffentlicht in:	Infect Immun
Hauptverfasser:	Haneberg, Bjørn, Dalseg, Rolf, Wedege, Elisabeth, Høiby, E. Arne, Haugen, Inger Lise, Oftung, Fredrik, Andersen, Svein Rune, Næss, Lisbeth Meyer, Aase, Audun, Michaelsen, Terje E., Holst, Johan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Microbial Immunity and Vaccines
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108057/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9529050/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.4.1334-1341.1998
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