Intranasal Administration of a Meningococcal Outer Membrane Vesicle Vaccine Induces Persistent Local Mucosal Antibodies and Serum Antibodies with Strong Bactericidal Activity in Humans

A nasal vaccine, consisting of outer membrane vesicles (OMVs) from group B Neisseria meningitidis, was given to 12 volunteers in the form of nose drops or nasal spray four times at weekly intervals, with a fifth dose 5 months later. Each nasal dose consisted of 250 μg of protein, equivalent to 10 ti...

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Detalhes bibliográficos
Main Authors: Haneberg, Bjørn, Dalseg, Rolf, Wedege, Elisabeth, Høiby, E. Arne, Haugen, Inger Lise, Oftung, Fredrik, Andersen, Svein Rune, Næss, Lisbeth Meyer, Aase, Audun, Michaelsen, Terje E., Holst, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC108057/
https://ncbi.nlm.nih.gov/pubmed/9529050
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