Polymorphism in the Bordetella pertussis Virulence Factors P.69/Pertactin and Pertussis Toxin in The Netherlands: Temporal Trends and Evidence for Vaccine-Driven Evolution

The Bordetella pertussis proteins P.69 (also designated pertactin) and pertussis toxin are important virulence factors and have been shown to confer protective immunity in animals and humans. Both proteins are used in the new generation of acellular pertussis vaccines (ACVs), and it is therefore imp...

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Главные авторы: Mooi, Frits R., van Oirschot, Hans, Heuvelman, Kees, van der Heide, Han G. J., Gaastra, Wim, Willems, Rob J. L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 1998
Предметы:
Microbial Immunity and Vaccines
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC107955/
https://ncbi.nlm.nih.gov/pubmed/9453625
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