Signature for Long-Term Vaccine-Mediated Control of a Simian and Human Immunodeficiency Virus 89.6P Challenge: Stable Low-Breadth and Low-Frequency T-Cell Response Capable of Coproducing Gamma Interferon and Interleukin-2

In 2001, we reported 20 weeks of control of challenge with the virulent 89.6P chimera of simian and human immunodeficiency viruses (SHIV-89.6P) by a Gag-Pol-Env vaccine consisting of DNA priming and modified vaccinia virus Ankara boosting. Here we report that 22 out of 23 of these animals successful...

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Detalhes bibliográficos
Main Authors: Sadagopal, Shanmugalakshmi, Amara, Rama Rao, Montefiori, David C., Wyatt, Linda S., Staprans, Silvija I., Kozyr, Natalia L., McClure, Harold M., Moss, Bernard, Robinson, Harriet L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1075739/
https://ncbi.nlm.nih.gov/pubmed/15731219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.6.3243-3253.2005
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