Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic Footprinting

The proopiomelanocortin (POMC) gene is expressed in the pituitary and arcuate neurons of the hypothalamus. POMC arcuate neurons play a central role in the control of energy homeostasis, and rare loss-of-function mutations in POMC cause obesity. Moreover, POMC is the prime candidate gene within a hig...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: de Souza, Flávio S. J., Santangelo, Andrea M., Bumaschny, Viviana, Avale, María Elena, Smart, James L., Low, Malcolm J., Rubinstein, Marcelo
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2005
Ämnen:
Gene Expression
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069613/
https://ncbi.nlm.nih.gov/pubmed/15798195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.8.3076-3086.2005
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