Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

Here we describe a triple transgenic mouse system, which combines the tissue specificity of any Cre-transgenic line with the inducibility of the reverse tetracycline transactivator (rtTA)/tetracycline-responsive element (tet-O)-driven transgenes. To ensure reliable rtTA expression in a broad range o...

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Main Authors: Belteki, Gusztav, Haigh, Jody, Kabacs, Nikolett, Haigh, Katharina, Sison, Karen, Costantini, Frank, Whitsett, Jeff, Quaggin, Susan E., Nagy, Andras
格式: Artigo
語言:Inglês
出版: Oxford University Press 2005
主題:
Methods Online
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069131/
https://ncbi.nlm.nih.gov/pubmed/15784609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gni051
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