Development of a Cell-Based High-Throughput Specificity Screen Using a Hepatitis C Virus-Bovine Viral Diarrhea Virus Dual Replicon Assay

The hepatitis C virus (HCV) replicon is a unique system for the development of a high-throughput screen (HTS), since the analysis of inhibitors requires the quantification of a decrease in a steady-state level of HCV RNA. HCV replicon replication is dependent on host cell factors, and any toxic effe...

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Autors principals: O'Boyle, Donald R., Nower, Peter T., Lemm, Julie A., Valera, Lourdes, Sun, Jin-Hua, Rigat, Karen, Colonno, Richard, Gao, Min
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068622/
https://ncbi.nlm.nih.gov/pubmed/15793110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1346-1353.2005
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