In Vitro and In Vivo Activities of Macrolide Derivatives against Mycobacterium tuberculosis

Existing macrolides have never shown definitive clinical efficacy in tuberculosis. Recent reports suggest that ribosome methylation is involved in macrolide resistance in Mycobacterium tuberculosis, a mechanism that newer macrolides have been designed to overcome in gram-positive bacteria. Therefore...

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Detalhes bibliográficos
Main Authors: Falzari, Kanakeshwari, Zhu, Zhaohai, Pan, Dahua, Liu, Huiwen, Hongmanee, Poonpilas, Franzblau, Scott G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068601/
https://ncbi.nlm.nih.gov/pubmed/15793125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1447-1454.2005
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