In Vitro and In Vivo Activities of Macrolide Derivatives against Mycobacterium tuberculosis

Existing macrolides have never shown definitive clinical efficacy in tuberculosis. Recent reports suggest that ribosome methylation is involved in macrolide resistance in Mycobacterium tuberculosis, a mechanism that newer macrolides have been designed to overcome in gram-positive bacteria. Therefore...

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Autores principales: Falzari, Kanakeshwari, Zhu, Zhaohai, Pan, Dahua, Liu, Huiwen, Hongmanee, Poonpilas, Franzblau, Scott G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Clinical Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068601/
https://ncbi.nlm.nih.gov/pubmed/15793125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1447-1454.2005
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