Early Selection of a New UL97 Mutant with a Severe Defect of Ganciclovir Phosphorylation after Valaciclovir Prophylaxis and Short-Term Ganciclovir Therapy in a Renal Transplant Recipient

We describe the emergence of a new ganciclovir resistance mutation in the UL97 gene of human cytomegalovirus, deletion of codon 601, after valaciclovir and short-term ganciclovir therapy following kidney transplantation. Its role in ganciclovir resistance was supported by decreased ganciclovir phosp...

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Détails bibliographiques
Auteurs principaux: Hantz, Sébastien, Michel, Detlef, Fillet, Anne-Marie, Guigonis, Vincent, Champier, Gaël, Mazeron, Marie-Christine, Bensman, Albert, Denis, François, Mertens, Thomas, Dehee, Axelle, Alain, Sophie
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068598/
https://ncbi.nlm.nih.gov/pubmed/15793144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1580-1583.2005
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