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Role of P-Glycoprotein in Distribution of Nelfinavir across the Blood-Mammary Tissue Barrier and Blood-Brain Barrier

As a first approach in understanding the possible efficacy and toxicity of human immunodeficiency virus protease inhibitors during breast feeding, the milk-to-plasma ratio of nelfinavir was determined in lactating rats. The milk-to-plasma ratio of nelfinavir was determined to be 0.56 ± 0.10 (means ±...

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Detalhes bibliográficos
Main Authors: Edwards, Jeffrey E., Alcorn, Jane, Savolainen, Juoko, Anderson, Bradley D., McNamara, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068594/
https://ncbi.nlm.nih.gov/pubmed/15793156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1626-1628.2005
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