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Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control
The role of protein arginine methylation in the DNA damage checkpoint response and DNA repair is largely unknown. Herein we show that the MRE11 checkpoint protein is arginine methylated by PRMT1. Mutation of the arginines within MRE11 severely impaired the exonuclease activity of MRE11 but did not i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1065720/ https://ncbi.nlm.nih.gov/pubmed/15741314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1279805 |
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