Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint

The hSNF5 subunit of human SWI/SNF ATP-dependent chromatin remodeling complexes is a tumor suppressor that is inactivated in malignant rhabdoid tumors (MRTs). Here, we report that loss of hSNF5 function in MRT-derived cells leads to polyploidization and chromosomal instability. Re-expression of hSNF...

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Autori principali: Vries, Robert G.J., Bezrookove, Vladimir, Zuijderduijn, Lobke M.P., Kia, Sima Kheradmand, Houweling, Ada, Oruetxebarria, Igor, Raap, Anton K., Verrijzer, C. Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2005
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1065719/
https://ncbi.nlm.nih.gov/pubmed/15769941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.335805
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