Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function

Oxidative stress leads to increased risk for osteoarthritis (OA) but the precise mechanism remains unclear. We undertook this study to clarify the impact of oxidative stress on the progression of OA from the viewpoint of oxygen free radical induced genomic instability, including telomere instability...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yudoh, Kazuo, van Trieu, Nguyen, Nakamura, Hiroshi, Hongo-Masuko, Kayo, Kato, Tomohiro, Nishioka, Kusuki
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2005
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1065334/
https://ncbi.nlm.nih.gov/pubmed/15743486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1499
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