Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production

The mechanism of endothelin-1 (ET-1)-induced nitric oxide (NO) production, MMP-1 production and MMP-13 production was investigated in human osteoarthritis chondrocytes. The cells were isolated from human articular cartilage obtained at surgery and were cultured in the absence or presence of ET-1 wit...

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Bibliografiske detaljer
Main Authors: Manacu, Christina Alexandra, Martel-Pelletier, Johanne, Roy-Beaudry, Marjolaine, Pelletier, Jean-Pierre, Fernandes, Julio C, Shipkolye, Fazool S, Mitrovic, Dragoslav R, Moldovan, Florina
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2005
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1065327/
https://ncbi.nlm.nih.gov/pubmed/15743480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1489
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