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Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition

Platelet activation is a hallmark of severe preeclampsia, and platelet PGH synthase 1–derived (PGHS1-derived) thromboxane A(2) (TxA(2)) has been implicated in its pathogenesis. However, genetic disruption of PGHS1 delays parturition. We created hypomorphic PGHS1 (PGHS1(Neo/Neo)) mice, in which the s...

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Bibliografiset tiedot
Päätekijät: Yu, Ying, Cheng, Yan, Fan, Jinjin, Chen, Xin-Sheng, Klein-Szanto, Andres, FitzGerald, Garret A., Funk, Colin D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2005
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064983/
https://ncbi.nlm.nih.gov/pubmed/15776109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523683
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