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Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition
Platelet activation is a hallmark of severe preeclampsia, and platelet PGH synthase 1–derived (PGHS1-derived) thromboxane A(2) (TxA(2)) has been implicated in its pathogenesis. However, genetic disruption of PGHS1 delays parturition. We created hypomorphic PGHS1 (PGHS1(Neo/Neo)) mice, in which the s...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1064983/ https://ncbi.nlm.nih.gov/pubmed/15776109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523683 |
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