Crystal Structures of the BlaI Repressor from Staphylococcus aureus and Its Complex with DNA: Insights into Transcriptional Regulation of the bla and mec Operons

The 14-kDa BlaI protein represses the transcription of blaZ, the gene encoding β-lactamase. It is homologous to MecI, which regulates the expression of mecA, the gene encoding the penicillin binding protein PBP2a. These genes mediate resistance to β-lactam antibiotics in staphylococci. Both represso...

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Main Authors: Safo, Martin K., Zhao, Qixun, Ko, Tzu-Ping, Musayev, Faik N., Robinson, Howard, Scarsdale, Neel, Wang, Andrew H.-J., Archer, Gordon L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064009/
https://ncbi.nlm.nih.gov/pubmed/15716455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.5.1833-1844.2005
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