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Engineering of Plasmin-Resistant Forms of Streptokinase and Their Production in Bacillus subtilis: Streptokinase with Longer Functional Half-Life

The short in vivo half-life of streptokinase limits its efficacy as an efficient blood clot-dissolving agent. During the clot-dissolving process, streptokinase is processed to smaller intermediates by plasmin. Two of the major processing sites are Lys59 and Lys386. We engineered two versions of stre...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Wu, Xu-Chu, Ye, Ruiqiong, Duan, Yanjun, Wong, Sui-Lam
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 1998
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC106333/
https://ncbi.nlm.nih.gov/pubmed/9501422
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