Engineering of Plasmin-Resistant Forms of Streptokinase and Their Production in Bacillus subtilis: Streptokinase with Longer Functional Half-Life

The short in vivo half-life of streptokinase limits its efficacy as an efficient blood clot-dissolving agent. During the clot-dissolving process, streptokinase is processed to smaller intermediates by plasmin. Two of the major processing sites are Lys59 and Lys386. We engineered two versions of stre...

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Pubblicato in:	Appl Environ Microbiol
Autori principali:	Wu, Xu-Chu, Ye, Ruiqiong, Duan, Yanjun, Wong, Sui-Lam
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Enzymology and Protein Engineering
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC106333/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9501422/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.64.3.824-829.1998
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