Control of Mammalian Circadian Rhythm by CKIɛ-Regulated Proteasome-Mediated PER2 Degradation

The mammalian circadian regulatory proteins PER1 and PER2 undergo a daily cycle of accumulation followed by phosphorylation and degradation. Although phosphorylation-regulated proteolysis of these inhibitors is postulated to be essential for the function of the clock, inhibition of this process has...

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Bibliographic Details
Main Authors: Eide, Erik J., Woolf, Margaret F., Kang, Heeseog, Woolf, Peter, Hurst, William, Camacho, Fernando, Vielhaber, Erica L., Giovanni, Andrew, Virshup, David M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061645/
https://ncbi.nlm.nih.gov/pubmed/15767683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.7.2795-2807.2005
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