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Protein phosphatase 1 regulates the stability of the circadian protein PER2
The circadian clock is regulated by a transcription/translation negative feedback loop. A key negative regulator of circadian rhythm in mammals is the PER2 (mammalian PERIOD 2) protein. Its daily degradation at the end of the night accompanies de-repression of transcription. CKIϵ (casein kinase I ϵ)...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1570171/ https://ncbi.nlm.nih.gov/pubmed/16813562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060678 |
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