Impaired Monocyte Maturation in Response to CpG Oligodeoxynucleotide Is Related to Viral RNA Levels in Human Immunodeficiency Virus Disease and Is at Least Partially Mediated by Deficiencies in Alpha/Beta Interferon Responsiveness and Production

The biological activity of CpG oligodeoxynucleotide 2216 (ODN2216), a Toll-like receptor 9 agonist, was investigated with monocytes from human immunodeficiency virus (HIV)-negative and HIV-positive (HIV+) donors. Exposure of peripheral blood mononuclear cells to CpG ODN2216 led to decreased expressi...

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Detalhes bibliográficos
Main Authors: Jiang, Wei, Lederman, Michael M., Salkowitz, Janelle R., Rodriguez, Benigno, Harding, Clifford V., Sieg, Scott F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061539/
https://ncbi.nlm.nih.gov/pubmed/15767412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.7.4109-4119.2005
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