Variants of Human Immunodeficiency Virus Type 1 That Efficiently Use CCR5 Lacking the Tyrosine-Sulfated Amino Terminus Have Adaptive Mutations in gp120, Including Loss of a Functional N-Glycan

By selecting the R5 human immunodeficiency virus type 1 (HIV-1) strain JR-CSF for efficient use of a CCR5 coreceptor with a badly damaged amino terminus [i.e., CCR5(Y14N)], we previously isolated variants that weakly utilize CCR5(Δ18), a low-affinity mutant lacking the normal tyrosine sulfate-contai...

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Bibliographic Details
Main Authors: Platt, Emily J., Shea, Danielle M., Rose, Patrick P., Kabat, David
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061536/
https://ncbi.nlm.nih.gov/pubmed/15767436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.7.4357-4368.2005
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