Consequences of Immunodominant Epitope Deletion for Minor Influenza Virus-Specific CD8(+)-T-Cell Responses

The extent to which CD8(+) T cells specific for other antigens expand to compensate for the mutational loss of the prominent D(b)NP(366) and D(b)PA(224) epitopes has been investigated using H1N1 and H3N2 influenza A viruses modified by reverse genetics. Significantly increased numbers of CD8(+) K(b)...

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Bibliographische Detailangaben
Hauptverfasser: Andreansky, Samita S., Stambas, John, Thomas, Paul G., Xie, Weidong, Webby, Richard J., Doherty, Peter C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061524/
https://ncbi.nlm.nih.gov/pubmed/15767433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.7.4329-4339.2005
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