Human Papillomavirus Type 16 E1(∧)E4-Induced G(2) Arrest Is Associated with Cytoplasmic Retention of Active Cdk1/Cyclin B1 Complexes

Human papillomavirus type 16 (HPV16) can cause cervical cancer. Expression of the viral E1(∧)E4 protein is lost during malignant progression, but in premalignant lesions, E1(∧)E4 is abundant in cells supporting viral DNA amplification. Expression of 16E1(∧)E4 in cell culture causes G(2) cell cycle a...

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Autores principales: Davy, Clare E., Jackson, Deborah J., Raj, Kenneth, Peh, Woei Ling, Southern, Shirley A., Das, Papia, Sorathia, Rina, Laskey, Peter, Middleton, Kate, Nakahara, Tomomi, Wang, Qian, Masterson, Phillip J., Lambert, Paul F., Cuthill, Scott, Millar, Jonathan B. A., Doorbar, John
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061520/
https://ncbi.nlm.nih.gov/pubmed/15767402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.7.3998-4011.2005
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