Human Papillomavirus Type 16 E1(∧)E4-Induced G(2) Arrest Is Associated with Cytoplasmic Retention of Active Cdk1/Cyclin B1 Complexes

Human papillomavirus type 16 (HPV16) can cause cervical cancer. Expression of the viral E1(∧)E4 protein is lost during malignant progression, but in premalignant lesions, E1(∧)E4 is abundant in cells supporting viral DNA amplification. Expression of 16E1(∧)E4 in cell culture causes G(2) cell cycle a...

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Main Authors: Davy, Clare E., Jackson, Deborah J., Raj, Kenneth, Peh, Woei Ling, Southern, Shirley A., Das, Papia, Sorathia, Rina, Laskey, Peter, Middleton, Kate, Nakahara, Tomomi, Wang, Qian, Masterson, Phillip J., Lambert, Paul F., Cuthill, Scott, Millar, Jonathan B. A., Doorbar, John
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061520/
https://ncbi.nlm.nih.gov/pubmed/15767402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.7.3998-4011.2005
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